Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells
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Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa.
Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PA...
متن کاملAnti-oxidant and anti-inflammatory cyclic diarylheptanoids from Alnus japonica stem bark
A new cyclic diarylheptanoid namely alnuheptanoid B (3), along with four known cyclic diarylheptanoids: myricanone (1), (+)-S-myricanol (2), myricanone 5-O--D-glucopyranoside (4), and (+)-S-myricanol 5-O--D-glucopyranoside (5) were isolated from the EtOAc fraction of Alnus japonica Steud (family: Betulaceae) stem bark. Their structures were established by different spectroscopic analyses, as ...
متن کاملAntiproliferative and Pro-Apoptotic Activity of Diarylheptanoids Isolated from the Bark of Alnus japonica in Human Leukemia Cell Lines.
Alnus japonica Steud is a tree that grows in damp areas of mountain valleys and has been used as a traditional medicine in Asia. We investigated the antiproliferative activity of hirsutanone (Hir) and oregonin (Ore) in human cancer cell lines and elucidated their mechanisms of action. A cytotoxicity study using a panel of 12 human cancer and 4 normal cell lines indicated that Hir exhibited pote...
متن کاملAnti-oxidant and anti-inflammatory cyclic diarylheptanoids from Alnus japonica stem bark
A new cyclic diarylheptanoid namely alnuheptanoid B (3), along with four known cyclic diarylheptanoids: myricanone (1), (+)-S-myricanol (2), myricanone 5-O--D-glucopyranoside (4), and (+)-S-myricanol 5-O--D-glucopyranoside (5) were isolated from the EtOAc fraction of Alnus japonica Steud (family: Betulaceae) stem bark. Their structures were established by different spectroscopic analyses, as ...
متن کاملAntimicrobial Compounds from Alnus Rubra
The methanol extract of the bark of Ahus rubra showed antimicrobial activity against Gram-positive and Gramnegative bacteria. Diarylheptanoid and its glycoside (oregonin) were identijied as the two constituents responsible for this activity.
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ژورنال
عنوان ژورنال: Chemico-Biological Interactions
سال: 2016
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2016.02.019